Antineutrophil Cytoplasmic Antibodies in Patients Treated With Methimazole
نویسندگان
چکیده
Abstract Introduction: Antithyroid drugs (ATDs) are widely used for the treatment of hyperthyroidism. Most side effects these medications mild and emerge within first months treatment. In contrast, antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is a severe adverse event whose occurrence increases with increasing time Vasculitis more frequently associated propylthiouracil than methimazole, but latter has also been related to ANCA even clinically manifest vasculitis. Many patients develop during methimazole do not exhibit signs/symptoms Objective: We previously reported relatively high frequency (20%) in exposed none them exhibited clinical manifestations on that occasion. continued follow up report here their evolution after 2 years. Methods: Seventeen were followed years detection (ANCA). Results: Eight had at least 6 months. During following 24 months, continuing without ATD, developed apparent last assessment, five no longer ANCA, while persisted three. Nine The medication was immediately discontinued when detected. After this detection, 3 (n = 1), 2), 9 12 18 1). follow-up negative two who received therefore receiving drug 21 respectively. other 7 remained positive. Conclusion: Although necessarily presence inverse undefined appears be low. Thus, measurement would recommended asymptomatic immediate discontinuation drug, if detected eventually, may required. Reference: Antineutrophil treated methimazole: prospective Brazilian study. Andrade GC, Maia FCP, Mourão GF, Rosario PW, Calsolari MR. Braz J Otorhinolaryngol. 2019; 85:636-41.
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ژورنال
عنوان ژورنال: Journal of the Endocrine Society
سال: 2021
ISSN: ['2472-1972']
DOI: https://doi.org/10.1210/jendso/bvab048.1883